MULTICENTRIC STUDY OF THE INVITRO SUSCEPT IBILITY OF GENITAL MYCOPLASMAS TO ANTIBIOTICS

The in vitro susceptibility of Ureaplasma urealyticum (Uu) and Mycopla sma hominis (Mh) was evaluated in a multicentric study performed in se ven hospitals from different geographic areas in France. During a thre e month period, 324 Uu and 72 Mh clinical isolates were tested using a system ready for use, SIR Mycoplasma (Sanofi Diagnostics Pasteur). Fo r Uu, the percentage of strains intermediate (I) or resistant (R) was as follows : doxycycline (3), minocycline (2.5), lymecycline (6.7), er ythromycin (72, most I), josamycin (0.9), clindamycin (88), pristinamy cin (0.3), ofloxacin (34, most I). For Mh, the percentage of strains I or R was respectively : doxycycline (2.7), minocycline (5.5), lymecyc line (15.2), erythromycin (100), clindamycin (1.4), ofloxacin (2.7), j osamycin (0) and pristinamycin (0). Comparable results were observed i n the different geographic areas. The frequency of aquired resistances does not justify modifications in the usual treatment of genital myco plasma infections but leads to monitor their susceptibility to antibio tics.