TISSUE PENETRATION OF AMOXICILLIN-CLAVULA NIC ACID FOR ANTIBIOPROPHYLAXIS IN COLONIC AND RECTAL SURGERY

Tissue penetration of amoxicillin and clavulanic acid given for antibi otic prophylax's was studied in 15 patients. On induction of anesthesi a patients were given 2 g amoxicillin and 200 mg clavulanic acid. The same dose was given two hours later. At time of surgical incision amox icillin and clavulanate levels were 15.9 +/- 7.7 mug/g and 2.23 +/- 2. 69 mug/g in abdominal wall fat and 16.6 +/- 10.5 and 1.72 +/- 1.35 mug /g in epiploic fat, respectively. Similar levels were measured at time of closure of the abdomen. In colonic wall, amoxicillin et clavulanat e levels were 22.7 +/- 13.4 mug/g and 2.65 +/- 2.35 mug/g. By comparis on with blood levels, tissue penetration of both drugs was 20 to 30 p. cent into fatty tissues and 60 to 70 p. cent into colonic wall.