INFLUENCE OF KETOPROFEN DRUG ON THE PHARM ACOKINETICS OF 2 FLUOROQUINOLONE DERIVATIVES IN MAN

The influence of a non steroidal antiinflammatory drug (NSAID), ketopr ofen, on the pharmacokinetics of two fluoroquinolone derivatives, pefl oxacin (P) and ofloxacin (O), was studied in ten healthy adult male vo lunteers. The subjects were given orally for three days the quinolone alone (P : 400 mg q 12 h and O : 200 mg q 12 h), with at least a one w eek interval between the two quinolone studies. On day 4, the first ki netic study of pefloxacin and ofloxacin was performed. During the thre e following days, the quinolone was administered in association with k etoprofen (100 mg daily). Another pharmacokinetic study of P and O was performed on day 8 and the kinetic data obtained were compared to tho se found on day 4. During the two kinetic studies (D4 and D8), blood s amples were taken at times 0, 1, 2, 3, 4, 6, 8, 10, 12 et 24 h and uri ne was collected during the time-periods 0-4 h, 4-8 h, 8-12 h and 12 2 4 h. Plasma and urine concentrations of the active P and O drug were m easured by microbiological assay. Ketoprofen administered for three da ys with the fluoroquinolone derivative induced no statistical modifica tion in the kinetic parameters of both P and O : peak plasma levels, t ime to peak level, areas under the curve, apparent volume of distribut ion, total and renal clearances.