THE PROGNOSTIC VALUE OF SERUM ESTRADIOL, PROGESTERONE, TESTOSTERONE AND FREE TESTOSTERONE LEVELS IN DETECTING EARLY ABORTIONS

Objective: Hormonal levels in early pregnancy may have predictive valu e in regard to outcome of pregnancy. In this study, the levels of estr adiol (E2), progesterone (P), total testosterone (tT) and free testost erone (fT) were investigated in this respect. Materials and method: Se venty women with early pregnancies of 6-12 weeks who applied to the ho spital for a pregnancy test were included into this study and were div ided into three groups according to their final diagnosis. Group 1 con sisted of 20 patients with anembryonic pregnancies, group 2 consisted of 20 patients with missed abortion and group 3 had 30 patients with n ormal pregnancies. Serum levels of E2, P, fi and tT were measured in e very patient and the ratio of fT to tT was calculated (fT ratio). Resu lts: E2, P and tT levels in patients with missed abortion or anembryon ic pregnancies were significantly lower than those in the normal group , whereas fT ratio was significantly higher, The level of P over 12.3 ng/ml was found to be sensitive and specific with respect to detecting a normal pregnancy (95% and 90%, respectively). All patients whose fT ratios were 1.05 and higher, subsequently miscarried whereas the ones whose fT ratios were lower than 0.84 were considered as normal pregna ncies. Conclusion: Serum P levels and fT ratio in early pregnancies ca n be used as a screening test with high sensitivity and specifity to p redict a normal pregnancy.