S. Aksoy et al., THE PROGNOSTIC VALUE OF SERUM ESTRADIOL, PROGESTERONE, TESTOSTERONE AND FREE TESTOSTERONE LEVELS IN DETECTING EARLY ABORTIONS, European journal of obstetrics, gynecology, and reproductive biology, 67(1), 1996, pp. 5-8
Objective: Hormonal levels in early pregnancy may have predictive valu
e in regard to outcome of pregnancy. In this study, the levels of estr
adiol (E2), progesterone (P), total testosterone (tT) and free testost
erone (fT) were investigated in this respect. Materials and method: Se
venty women with early pregnancies of 6-12 weeks who applied to the ho
spital for a pregnancy test were included into this study and were div
ided into three groups according to their final diagnosis. Group 1 con
sisted of 20 patients with anembryonic pregnancies, group 2 consisted
of 20 patients with missed abortion and group 3 had 30 patients with n
ormal pregnancies. Serum levels of E2, P, fi and tT were measured in e
very patient and the ratio of fT to tT was calculated (fT ratio). Resu
lts: E2, P and tT levels in patients with missed abortion or anembryon
ic pregnancies were significantly lower than those in the normal group
, whereas fT ratio was significantly higher, The level of P over 12.3
ng/ml was found to be sensitive and specific with respect to detecting
a normal pregnancy (95% and 90%, respectively). All patients whose fT
ratios were 1.05 and higher, subsequently miscarried whereas the ones
whose fT ratios were lower than 0.84 were considered as normal pregna
ncies. Conclusion: Serum P levels and fT ratio in early pregnancies ca
n be used as a screening test with high sensitivity and specifity to p
redict a normal pregnancy.