Nj. Lench et al., INVESTIGATION OF CHROMOSOME 9Q22.3-Q31 DNA MARKER LOSS IN ODONTOGENICKERATOCYSTS, European journal of cancer. Part B, Oral oncology, 32(3), 1996, pp. 202-206
Multiple basal cell carcinomas and odontogenic keratocysts of the jaws
are a feature of the inherited naevoid basal cell carcinoma syndrome
(NBCCS), although both occur more commonly as single, sporadic cases.
The NBCCS gene has been mapped to chromosome 9q22.3-q31 and loss of he
terozygosity for DNA markers from this region has been observed in fam
ilial and sporadic basal cell carcinomas. Based on these observations,
we undertook a pilot study to determine if a similar pattern of chrom
osome loss occurs in odontogenic keratocysts. DNA extracted from micro
dissected odontogenic keratocyst epithelium was examined for loss of h
eterozygosity for six polymorphic DNA markers mapping to human chromos
ome 9q22.3-q31. Allelotype loss was detected in epithelium from three,
single, sporadic odontogenic keratocysts. These results implicate hom
ozygous inactivation of the NBCCS gene in the initiation and progressi
on of the odontogenic keratocyst. Copyright (C) 1996 Elsevier Science
Ltd