EPSILON-4 ALLELE OF APOLIPOPROTEIN-E INCREASES RISK OF ALZHEIMERS-DISEASE IN A CHINESE POPULATION

Authors
HONG CJ LIU TY LIU HC WANG SJ FUH JL CHI CW LEE KY SIM CB
Citation
Cj. Hong et al., EPSILON-4 ALLELE OF APOLIPOPROTEIN-E INCREASES RISK OF ALZHEIMERS-DISEASE IN A CHINESE POPULATION, Neurology, 46(6), 1996, pp. 1749-1751
Citations number
10
Categorie Soggetti
Clinical Neurology
Journal title
Neurology → ACNP
ISSN journal
00283878
Volume
46
Issue
6
Year of publication
1996
Pages
1749 - 1751
Database
ISI
SICI code
0028-3878(1996)46:6<1749:EAOAIR>2.0.ZU;2-B
Abstract
We examined the apolipoprotein E genotype in 56 Chinese patients with late-onset sporadic Alzheimer's disease (AD) and 57 Chinese control su bjects of similar age. The frequency of epsilon 4 in the AD group was significantly higher than that in the control group (23.2% versus 7.9% , p = 0.003). The odds ratio for AD in individuals with either one or two epsilon 4 was 2.96 (95% CI 1.11 to 8.03). The linear trend for AD in proportion to alleles of epsilon 4 was also significant (chi(2) = 8 .2, p = 0.004). Our results support the association between epsilon 4 and AD in the Chinese.