INDIUM-111-PENTETREOTIDE SCINTIGRAPHY IN CHILDREN WITH NEUROBLAST-DERIVED TUMORS

Citation
L. Manil et al., INDIUM-111-PENTETREOTIDE SCINTIGRAPHY IN CHILDREN WITH NEUROBLAST-DERIVED TUMORS, The Journal of nuclear medicine, 37(6), 1996, pp. 893-896
Citations number
19
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
ISSN journal
01615505
Volume
37
Issue
6
Year of publication
1996
Pages
893 - 896
Database
ISI
SICI code
0161-5505(1996)37:6<893:ISICWN>2.0.ZU;2-Q
Abstract
The somatostatin analog (111)ln-pentetreotide was evaluated in 11 chil dren with sympathetic embryonic cell-derived tumors. Methods: Six neur oblastomas, four ganglioneuroblastomas and one ganglioneuroma (benign) were imaged 4 and 24 hr after injection of (111)ln-pentetreotide (5 M Bq/kg) and 24 hr after administration of (123)-metaiodobenzylguanidine (MIBG) (3.7 MBq/kg). Results: Primary tumor was detected with both tr acers in four of the five patients studied before surgery (one Stage I II neuroblastoma, one Stage IV neuroblastoma, one Stage IVs neuroblast oma, one ganglioneuroblastoma), but the ganglioneuroma was not localiz ed. Detection of bone marrow metastases was clearly better with (111)l n-pentetreotide in two patients, similar or slightly better with MIBG in six and (true) negative with both procedures in three. The positivi ty rate of (111)ln-pentetreotide for imaging of metastases was higher in undifferentiated malignant tumors (six neuroblastomas: two very pos itive, three positive, one true-negative) than in histologically well- differentiated tumors (four ganglioneuroblastomas: three weakly positi ve, one true-negative). All patients with positive (111)ln-pentetreoti de imaging results had elevated urinary catecholamine levels, and the two most (111)ln-pentetreotide-positive metastases were found in neuro blastomas from children with an aneuploid primary tumor. The (111)ln-p entetreotide and MIBG results were only partly correlated with bone ma rrow status, as assessed by immunocytological and histological studies at the time of scanning. Conclusion: Abnormalities detected in (111)l n-pentetreotide uptake were slightly different from those seen with MI BG, but (111)ln-pentetreotide is unlikely to replace MIBG as a first-l ine routine method in neuroblast-derived tumors. However, some MIBG-ne gative tumor sites were detected by (111)ln-pentetreotide in patients with neuroblastomas. Thus, (111)ln-pentetreotide could provide novel i nformation on the biology and prognosis of tumors whose clinical signi ficance remains to be defined.