H. Takekawa et al., TL-201 UPTAKE, HISTOPATHOLOGICAL DIFFERENTIATION AND NA-K ATPASE IN LUNG ADENOCARCINOMA, The Journal of nuclear medicine, 37(6), 1996, pp. 955-958
To clarify differences in accumulation in Tl-201 scintigraphy, we exam
ined the relationship between uptake of Tl-201, histopathological diff
erentiation and Na-K ATPase. Methods: Thallium-201 SPECT was performed
twice: 15 min (early scan) and 120 min (delayed scan) after intraveno
us injection of 3 mCi Tl-201-chloride. The uptake ratio of Tl-201 was
calculated and compared with the grade of differentiation and the stai
ning pattern of Na-K ATPase. Results: The sensitivity of Tl-201 SPECT
for well-differentiated adenocarcinomas was lower than that for modera
tely and poorly differentiated ones. The uptake ratio on the delayed s
can was significantly lower in the well-differentiated group than that
in the moderately and poorly differentiated groups. This parameter wa
s also significantly higher in the Na-K ATPase-positive group than the
-negative group. Conclusions: These results indicate that the uptake
ratio of Tl-201 SPECT may be a noninvasive indicator of the grade of p
athological differentiation of adenocarcinoma and provide insight into
the relationship among Tl-201 SPECT, malignancy and Na-K ATPase.