A premature neonate (gestational age, 25 weeks) with multiple prematur
ity-related problems developed primary cutaneous aspergillosis due to
Aspergillus fumigatus on the 30th day of life. The infection developed
in an area that had been macerated by adhesive tape. During the infec
tion, renovation of the hospital was in progress near the neonatal int
ensive care unit. The infection was cured with a short course of thera
py with amphotericin B. Five cases of primary cutaneous aspergillosis
in neonates have been preciously reported in the English-language lite
rature. We review these cases and discuss the risk factors and favorab
le outcome of the disease when treatment with amphotericin B is instit
uted.