NEUROMUSCULAR BLOCKING-AGENTS - APPROACHES TO SHORT-ACTING COMPOUNDS .2. BIS-THIAZOLIUM SALTS

A series of bis-thiazolium diesters has been prepared. All were substa ntially less potent than atracurium and all showed appreciable vagal b lockade at neuromuscular blocking doses. N-Benzyl quaternary substitue nts shortened the duration of neuromuscular blockade significantly. Ne uromuscular blocking potency was greater and duration of action least in bis-N-3,4,5-trimethoxybenzylthiazolium salts, though each of these effects was at its optimum at differing interquaternary chain separati ons.