SYNTHESIS AND PRELIMINARY DATA ON NEW SELECTIVE AND POTENT GASTRIC PROKINETIC SUBSTITUTED BENZAMIDES

Authors
DELCORONA L SIGNORELLI G PINZETTA A COPPI G
Citation
L. Delcorona et al., SYNTHESIS AND PRELIMINARY DATA ON NEW SELECTIVE AND POTENT GASTRIC PROKINETIC SUBSTITUTED BENZAMIDES, European journal of medicinal chemistry, 28(5), 1993, pp. 419-425
Citations number
17
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
28
Issue
5
Year of publication
1993
Pages
419 - 425
Database
ISI
SICI code
0223-5234(1993)28:5<419:SAPDON>2.0.ZU;2-I
Abstract
A series of amino-halogen-N-[2-aminoethyl] benzamides was synthesized and evaluated for enhancing gastric emptying. Compared to metocloprami de, domperidone and bromopride, a number of compounds were shown to be more active in enhancing gastric motility (rat stomach emptying), dev oid of dopaminergic D2-receptor antagonism (rat apomorphine test) and to be less toxic.