PLATELET-DERIVED GROWTH-FACTOR B-CHAIN HOMODIMER SUPPRESSING A CONVULSION OF EPILEPSY MODEL MOUSE EL

Authors
MASUDA Y MIURA N KAWARADA Y KAWAGOE M SHIMIZU T SUGIYAMA T HISHIKAWA Y
Citation
Y. Masuda et al., PLATELET-DERIVED GROWTH-FACTOR B-CHAIN HOMODIMER SUPPRESSING A CONVULSION OF EPILEPSY MODEL MOUSE EL, Biochemical and biophysical research communications, 223(1), 1996, pp. 60-63
Citations number
15
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
223
Issue
1
Year of publication
1996
Pages
60 - 63
Database
ISI
SICI code
0006-291X(1996)223:1<60:PGBHSA>2.0.ZU;2-2
Abstract
El mouse is a mutant which has epileptic convulsions after tossing-up stimulations and has a hippocampal dysfunction. Platelet-derived growt h factor B-chain homodimer has been reported to be a trophic factor of hippocampal neurons. We found that a recombinant PDGF-BB suppressed t he convulsions of El mice in a dose-dependent manner, Furthermore, thr ombin-treated mice manifested no convulsions, but thrombin receptor ac tivating peptide-treated ones had convulsions, These findings suggest that an abnormality in PDGF-BB release may make El mice susceptible to tonic-clonic convulsions. (C) 1996 Academic Press, Inc.