SYNTHESIS, STABILITY, AND RADIOLYTIC DECOMPOSITION OF C-14-LABELED MK0677

Authors
JONES AN DEAN DC JENKINS HJ MELILLO DG NARGUND RP WALLACE MA
Citation
An. Jones et al., SYNTHESIS, STABILITY, AND RADIOLYTIC DECOMPOSITION OF C-14-LABELED MK0677, Journal of labelled compounds & radiopharmaceuticals, 38(6), 1996, pp. 561-565
Citations number
2
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy","Biochemical Research Methods
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
38
Issue
6
Year of publication
1996
Pages
561 - 565
Database
ISI
SICI code
0362-4803(1996)38:6<561:SSARDO>2.0.ZU;2-1
Abstract
MK0677 is an orally active growth hormone secretagogue. The crystalliz ed carbon-14 labeled material was found to undergo radiolytic decompos ition via a peroxide intermediate which resulted in loss of the benzyl group. The rate was diminished when the tracer was crystallized from nitrogen-degassed solvents. Storage stability was best in aqueous etha nol.