EFFECTS OF GRANULOCYTE-COLONY-STIMULATING FACTOR ON THE HEMOSTATIC SYSTEM IN HEALTHY-VOLUNTEERS

We previously identified a receptor for granulocyte colony-stimulating factor (G-CSFR) on platelet membranes, and reported that G-CSF enhanc ed ADP-induced platelet aggregation. Here, we investigated the priming effect of G-CSF on the hemostatic system in healthy volunteers given G-CSF. Following the administration of rhG-CSF (10 mu g/kg for 30 min div) to 10 healthy volunteers, we found a significant elevation in the maximum platelet aggregation rate induced by ADP or collagen, thrombo xane B-2 level and amount of thrombin-antithrombin III complex. The D- D dimer and plasminogen activator inhibitor-1 showed no significant ch anges. These observations indicate that G-CSF administration may induc e hypercoagulability in susceptible subjects. Therefore, patients or d onors at risk of thrombosis or hypercoagulable state should be followe d carefully after G-CSF administration.