For a separation system producing multicomponent products, stream spli
tting besides stream bypassing has long been recognized as a technique
that always reduces total mass load (TML) and should always be prefer
red over sequential processing. Nevertheless, our preliminary analysis
has indicated that stream splitting can increase TML under certain ci
rcumstances which, in turn, may increase the cost of the system; furth
ermore, even when stream splitting reduces TML, it may increase the ma
ss load of one or more difficult separations and increase the cost of
the system. An exhaustive parametric study of a class of relatively si
mple problems is performed in this work to reveal the impact of stream
splitting on the sequencing of separation systems. Some significant o
bservations have been made, and some guidelines have been established
for evolutionarily improving separation system sequencing involving st
ream splitting.