PRODUCTION OF BIOLOGICALLY-ACTIVE SECONDARY METABOLITES IN SOLID-STATE FERMENTATION

Many practical and economical advantages have been attributed to the S olid State Fermentation (SSF) technique as compared with the submerged fermentation (SmF) process. Though, mostly used for food fermentation and for the production of some enzymes, SSF processes are a potential method for large-scale. production of bulk chemicals and for biotrans formation. In spite of the realization of the potential applications o f SSF systems to produce high value secondary metabolites, much effort s to obtain them through SSF route have not been made. Tile paper revi ews different types of biologically active secondary metabolites produ ced by SSF and different strategies and processes that helped or would be helpful in utilizing the SSF processes, especially for the product ion of biopharmaceuticals. Improvements to be undertaken in SSF proces ses for ensuring the use of SSF systems for the manufacture of biophar maceuticals are also dealt with.