INHIBITION OF MUCOSAL LIPID HYPEROXIDATION BY GREEN TEA EXTRACT IN 1,2-DIMETHYLHYDRAZINE-INDUCED RAT COLONIC CARCINOGENESIS

Authors
MATSUMOTO H YAMANE T INAGAKE M NAKATANI H IWATA Y TAKAHASHI T NISHIMURA H NISHINO H NAKAGAWA K MIYAZAWA T
Citation
H. Matsumoto et al., INHIBITION OF MUCOSAL LIPID HYPEROXIDATION BY GREEN TEA EXTRACT IN 1,2-DIMETHYLHYDRAZINE-INDUCED RAT COLONIC CARCINOGENESIS, Cancer letters, 104(2), 1996, pp. 205-209
Citations number
16
Categorie Soggetti
Oncology
Journal title
Cancer letters → ACNP
ISSN journal
03043835
Volume
104
Issue
2
Year of publication
1996
Pages
205 - 209
Database
ISI
SICI code
0304-3835(1996)104:2<205:IOMLHB>2.0.ZU;2-R
Abstract
Phosphatidylcholine hydroperoxide (PCOOH) measured using a chemilumine scence detector to examine colonic mucosal lipid hyperoxidation increa sed after injection of 1,2-dimethylhydrazine and green tea extract (GT E), which we previously showed inhibited. carcinogenesis and oxidative DNA damage in the gastrointestinal tract. Therefore, the hyperoxidati on of membrane phospholipids reflected well the degree of DNA damage a nd carcinogenic alteration, and may be a useful intermediate biomarker for initiation of carcinogenesis.