EFFECT OF THE ACE-INHIBITOR CERONAPRIL ON CEREBRAL BLOOD-FLOW IN HYPERTENSIVE PATIENTS

OBJECTIVE: To assess the effect of the angiotensin-converting enzyme i nhibitor ceronapril on cerebral blood flow (CBF) in patients with mode rate hypertension. DESIGN: Patients received chlorthalidone 25 mg for 4 weeks, and if diastolic blood pressure remained in the range of 100- 115 mm Hg, they were given titrated doses of ceronapril (10-40 mg/d ba sed on blood pressure response) in addition to chlorthalidone for 9 we eks. SETTING: Outpatient research clinic. SUBJECTS: Eligible patients had moderate essential hypertension (diastolic blood pressure 100-115 mm Hg) assessed when the patients were receiving no medications. Thirt een patients were entered into the study; 1 withdrew for reasons unrel ated to the study drug. Twelve patients (11 men, 1 woman; mean age 52 y) completed the study. INTERVENTION: ceronapril, given with chlorthal idone. MAIN OUTCOME MEASURES: CBF measurements were taken at the start and end of ceronapril therapy using intravenous Xe-133; blood pressur es were determined weekly. RESULTS: Mean arterial blood pressure decre ased from 130 +/- 4 to 120 +/- 7 mm Hg after 4 weeks of chlorthalidone administration, and fell further to 108 +/- 8 mm Hg after an addition al 9 weeks of combined chlorthalidone-ceronapril therapy (p<0.05). CBF fell from 44 +/- 15 to 34 +/- 5 mL/min/100 g during the 9 weeks of co mbined therapy (p = 0.05). No adverse effects consistent with decrease d CBF were observed. The decrease in CBF was not linearly correlated w ith the change in systemic blood pressure, but was strongly correlated (r = -0.937; p<0.001) with the initial CBF. CONCLUSIONS: The decrease in mean arterial blood pressure was not associated with a decrease in CBF. Patients with high CBF may be predisposed to a decrease in CBF w hen treated with ceronapril and chlorthalidone.