In this work, the citric acid production in solid state culture was pe
rformed, evaluating the isolated effect and interactions of particle s
ize and liquid phase employed, by means of the factorial design of fir
st order. The results indicate that the particle size is the most dete
rminant variable. An analysis comparing submerged and solid state in o
ptimal conditions was performed. When solid state culture was used, th
e productivity of citric acid was doubled, reducing the fermentation t
ime from 14 to 6 days, compared to the submerged culture, obtaining a
maximum citric acid concentration of 21.24 g/l.