ONLINE BIOMASS ESTIMATION USING A MODIFIED OXYGEN UTILIZATION RATE

Authors
PETKOV SB DAVIS RA
Citation
Sb. Petkov et Ra. Davis, ONLINE BIOMASS ESTIMATION USING A MODIFIED OXYGEN UTILIZATION RATE, Bioprocess engineering, 15(1), 1996, pp. 43-45
Citations number
5
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Bioprocess engineering → ACNP
ISSN journal
0178515X
Volume
15
Issue
1
Year of publication
1996
Pages
43 - 45
Database
ISI
SICI code
0178-515X(1996)15:1<43:OBEUAM>2.0.ZU;2-C
Abstract
A procedure for estimating biomass during batch fermentation from on-l ine gas analysis is presented. First, the respiratory quotient was use d to determine the fraction of the total oxygen utilization rate requi red for cell maintenance and growth versus product synthesis. The modi fied oxygen utilization rate was then used to estimate biomass on-line by integrating the oxygen balance for cell synthesis-maintenance. The method is illustrated for the case of L-lysine synthesis by Corynebac terium glutamicum.