ITA
ENG

STEREOSELECTIVE SYNTHESIS OF AMINOALKYL-SUBSTITUTED BETA-LACTAMS VIA CYCLOADDITION OF KETENES GENERATED FROM ALPHA-AMINO-ACIDS

Authors

PODLECH J

Citation

J. Podlech, STEREOSELECTIVE SYNTHESIS OF AMINOALKYL-SUBSTITUTED BETA-LACTAMS VIA CYCLOADDITION OF KETENES GENERATED FROM ALPHA-AMINO-ACIDS, Synlett, (6), 1996, pp. 582

Citations number

Categorie Soggetti

Chemistry Inorganic & Nuclear

Journal title

Synlett → ACNP

ISSN journal

09365214

Issue

Year of publication

1996

Database

ISI

SICI code

0936-5214(1996):6<582:SSOABV>2.0.ZU;2-1

Abstract

Photochemical rearrangement of diazoketones 1 - 8 (derived from suitab ly protected alpha-amino acids) in the presence of imines led to the d iastereoselective formation of aminoalkyl-substituted beta-lactams 10 - 17. The two diastereoisomeric trans-substituted ring systems were fo rmed with selectivities up to 93:7 and yields up to 90 %.