Kg. Shyu et al., CIRCULATING INTERCELLULAR-ADHESION MOLECULE-1 AND E-SELECTIN IN PATIENTS WITH ACUTE CORONARY SYNDROME, Chest, 109(6), 1996, pp. 1627-1630
To characterize the role of circulating intercellular adhesion molecul
e-1 (ICAM-1) and E-selectin in patients with acute coronary syndrome,
serum levels of ICAM-1 and E-selectin were measured by enzyme-linked i
mmunosorbent assay (ELISA), Group 1 comprised 17 patients with acute m
yocardial infarction; group 2 included 17 patients with unstable angin
a; and group 3 included 19 control subjects, These 53 patients all had
prolonged chest pain within 24 h and all underwent coronary angiograp
hy. Group 1 and 2 patients had significant coronary artery disease, wh
ile group 3 had normal coronary arteries, Blood samples were collected
at the emergency department before antiplatelet agents were given, Se
rum levels of ICAM-1 were higher in group 1 and 2 (383+/-27 and 337+/-
11 ng/mL, respectively) as compared with group 3 (282+/-18 ng/mL) (gro
up I vs 3, p<0.01; group 2 vs 3, p<0.05), The serum levels of ICAM-1 w
ere not significantly different between group 1 and 2, Serum levels of
E-selectin in group 1, 2, and 3 were 58+/-8, 51+/-4, and 58+/-5 ng/mL
, respectively, The serum levels of E-selectin showed no significant d
ifference among the three groups, In conclusion, serum levels of ICAM-
1 were elevated in patients with acute coronary syndrome within 24 h,
while the E-selectin levels did not change significantly. This finding
suggests that adhesion molecule may play an important role in the pos
trolling process of leukocyte-endothelial cell interaction in acute co
ronary syndrome.