EFFECT OF PHYSICOCHEMICAL PARAMETERS ON THE RETENTION OF SOME MONOAMINE-OXIDASE INHIBITORY DRUGS ON A POROUS GRAPHITIZED CARBON COLUMN

The retention of sixteen monoamine oxidase inhibitory drugs (proparlgy lamine derivatives) was determined on a porous graphitized carbon (PGC ) column using ethanol-water mixtures as eluents. The HPLC retention c haracteristics of drugs were correlated with their physicochemical pro perties using stepwise regression analysis and principal component (PC ) analysis. The dimensions of the matrices for PC loadings and variabl es was reduced using a non-linear mapping technique, varimax rotation and cluster analysis. It has been established that the drugs can be we ll separated on the PGC column in ethanol-water eluents. Calculations proved that the retention behavior of monoamine oxidase drugs on PGC c olumn is of mixed character: both steric and electronic parameters inf luence the retention.