URINARY GONADOTROPIN PEPTIDE (UGP) IN EGYPTIAN PATIENTS WITH BENIGN AND ADVANCED MALIGNANT UROLOGICAL DISEASE

Urinary gonadotropin peptide (UGP) levels were determined in urine sam ples from 450 Egyptian subjects to determine its relative level of exp ression in benign and malignant urological disease, and normal individ uals. The mean UGP level in patients with bladder cancer was 44-fold h igher than in patients with benign disease, and 81-fold higher than in normal individuals. At specificities of 95% and 100%, overall sensiti vities of 73% and 60%, respectively, were observed for the detection o f malignant disease. Mean UGP levels in patients with bladder cancer w ere significantly correlated with the stage and grade of malignant dis ease but did not vary significantly when stratified according to histo logical type of disease, nodal involvement or bilharzial association. UGP could be a potentially useful marker for the differentiation of be nign from malignant urological disease.