DOPAMINE D-3 AGONISTS DISRUPT SOCIAL-BEHAVIOR IN RATS

Behavioral studies were conducted in rats administered a selective D-3 agonist, 7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT) or 4aR ,10b propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907). B oth drugs induced disruption of huddling behavior in rats at doses tha t did not produce hyperlocomotion. The effects of the D-3 agonists wer e dependent upon dosage and time after administration. These results s uggest that D-3 receptors are concerned with social interaction in rat s.