Aa. Leonard et al., COMPLETE WITHDRAWAL OF IMMUNOSUPPRESSION IN ALLOGRAFT RECIPIENTS - A STUDY IN RHESUS-MONKEYS, Transplantation, 61(11), 1996, pp. 1648-1651
The influence of pretransplant blood transfusions on kidney allograft
survival after cessation of immunosuppressive treatment was studied in
11 rhesus monkeys. The animals were conditioned by three pretransplan
t blood transfusions, After an induction treatment with cyclosporine (
CsA), the immunosuppression was stopped and the natural course of the
graft was followed, In two monkeys long-term graft survival without im
munosuppression was obtained (2.5 and 4.25 years). In a third monkey,
permanent allograft acceptance was achieved after complete cessation o
f immunosuppression. The monkey is still alive with a well-functioning
graft for more than 13 years after cessation of immunosuppression, Th
is monkey had received CsA for 12 months, two MHC DR-matched blood tra
nsfusions, and no repeated mismatches between graft and blood transfus
ion donors, We speculate that blood transfusions may influence allogra
ft function in two opposite ways, As reported previously in man, MHC c
lass-II-matched transfusions appear to beneficially influence allograf
t survival. This effect seems to be negated by a mismatched MHC class
II antigen in the blood transfusion donor which is also present in the
organ donor-a so-called repeated mismatch, Further studies in rhesus
monkeys are required to confirm and extend these results, In the futur
e, these observations might help in developing a protocol that opens u
p the possibility of cessation of immunosuppression in transplant pati
ents.