Objective: To describe the causes and characteristics of hypoglossal n
erve palsy. Design: A review of 26 years of personal experience in a l
arge public hospital. Results: Twelfth-nerve palsies usually appear as
signs rather than symptoms. Tumors, predominantly malignant, produced
nearly half of the palsies (49 cases), while gunshot wounds made trau
ma (12) the second most common cause. Stroke (6), hysteria (6), multip
le sclerosis (6), surgery (5), Guillain-Barre neuropathy (4), and infe
ction (4) together accounted for about one third of the patients. Conc
lusion: Twelfth-nerve palsy proved to be an ominous sign, with only 15
% of patients experiencing complete or nearly complete recovery.