EVALUATION OF PATIENTS WITH MINIMALLY OBSTRUCTIVE CORONARY-ARTERY DISEASE AND ANGINA

Atherosclerotic coronary artery disease is a progressive process adver sely affecting the integrity of the coronary vasculature. In past year s, most studies have focused on the morphological changes leading to c ompromised coronary blood flow in atherosclerosis. However, in recent years it has become apparent that abnormal coronary vasomotor regulati on may precede or accompany gross morphological changes in coronary at herosclerotic disease. In fact, the pathophysiology of angina pectoris in many patients with risk factors for atherosclerosis and minimally obstructive disease may involve abnormal coronary vasomotor tone regul ation. The aim of the present article is to describe a clinical approa ch to patients with angina pectoris and minimally obstructive coronary artery disease based on current knowledge of coronary vasomotor regul ation.