CHOLESTEROL-FED RABBITS - STUDY OF THE RESPONSE OF THE VAS-DEFERENS TO ADRENERGIC AND NONADRENERGIC STIMULUS AND TO A KAPPA-OPIOID AGONIST

Authors
ALFARO MJ ORMAZABAL MJ GARCIAARROBA L MARTIN MI
Citation
Mj. Alfaro et al., CHOLESTEROL-FED RABBITS - STUDY OF THE RESPONSE OF THE VAS-DEFERENS TO ADRENERGIC AND NONADRENERGIC STIMULUS AND TO A KAPPA-OPIOID AGONIST, Journal of Pharmacy and Pharmacology, 48(4), 1996, pp. 433-436
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of Pharmacy and Pharmacology → ACNP
ISSN journal
00223573
Volume
48
Issue
4
Year of publication
1996
Pages
433 - 436
Database
ISI
SICI code
0022-3573(1996)48:4<433:CR-SOT>2.0.ZU;2-7
Abstract
The aim of the present study was to analyse the contractility of the i solated vas deferens from hypercholesterolaemic rabbits; for this purp ose we evaluated the contractile response induced by noradrenaline and by electrical stimulation. A significant increase in the amplitude of adrenergic and non-adrenergic responses was observed in vas deferens from hypercholesterolaemic rabbits. These data suggest an increase in the contractility of the smooth muscle in these animals.