STRUCTURE-ACTIVITY RELATIONSHIP OF NOVEL TALLIMUSTINE DERIVATIVES - SYNTHESIS AND ANTITUMOR-ACTIVITY

Authors
BARALDI PG BERIA I CACCIARI B CAPOLONGO L COZZI P MONGELLI N ROMAGNOLI R SPALLUTO G
Citation
Pg. Baraldi et al., STRUCTURE-ACTIVITY RELATIONSHIP OF NOVEL TALLIMUSTINE DERIVATIVES - SYNTHESIS AND ANTITUMOR-ACTIVITY, Bioorganic & medicinal chemistry letters, 6(11), 1996, pp. 1247-1252
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
11
Year of publication
1996
Pages
1247 - 1252
Database
ISI
SICI code
0960-894X(1996)6:11<1247:SRONTD>2.0.ZU;2-W
Abstract
Oligopeptide-like derivatives structurally related to the antitumor ag ent tallimustine, where one or two pyrrole rings were replaced by pyra zole or thiazole rings and bearing benzoyl nitrogen mustard or bromoac ryloyl moieties were synthesized and evaluated in vitro and in vivo ag ainst L1210 murine leukemia. Compounds 9 and 12 showed antitumor activ ity higher than or comparable with that of tallimustine. Copyright (C) 1996 Elsevier Science Ltd