ANTI-HUMAN-IMMUNODEFICIENCY-VIRUS ACTIVITY AND CYTOTOXICITY OF DERIVATIZED BUCKMINSTERFULLERENES

Authors
SCHUSTER DI WILSON SR SCHINAZI RF
Citation
Di. Schuster et al., ANTI-HUMAN-IMMUNODEFICIENCY-VIRUS ACTIVITY AND CYTOTOXICITY OF DERIVATIZED BUCKMINSTERFULLERENES, Bioorganic & medicinal chemistry letters, 6(11), 1996, pp. 1253-1256
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
11
Year of publication
1996
Pages
1253 - 1256
Database
ISI
SICI code
0960-894X(1996)6:11<1253:AAACOD>2.0.ZU;2-6
Abstract
Eleven new functional derivatives of C-60 have been tested for anti-HI V activity in peripheral blood mononuclear cells infected with HIV-1(L AV). Nine compounds displayed activity in the low micromolar range (EC (50)), three of them lower than any fullerene derivative reported to d ate. With one exception, these compounds displayed no cytotoxicity up to 100 mu M. Copyright (C) 1996 Elsevier Science Ltd