SYNTHESIS AND BIOLOGICAL EVALUATION OF A BICYCLO[7.4.1]ENEDIYNE

Authors
LEE S BAIN A SULIKOWSKI GA SOLOMON W ZEIN N
Citation
S. Lee et al., SYNTHESIS AND BIOLOGICAL EVALUATION OF A BICYCLO[7.4.1]ENEDIYNE, Bioorganic & medicinal chemistry letters, 6(11), 1996, pp. 1261-1264
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
11
Year of publication
1996
Pages
1261 - 1264
Database
ISI
SICI code
0960-894X(1996)6:11<1261:SABEOA>2.0.ZU;2-Q
Abstract
The synthesis of bicyclo[7.4.1]enediynes 2a and 2b are described. The bicyclo[7.4.1]enediyne 2b was found to be a poor DNA cleaver but did c ause damage to several protein isolates. Copyright (C) 1996 Elsevier S cience Ltd