EVALUATION OF COMPOUND-48 80 AS A MODEL OF IMMEDIATE HYPERSENSITIVITYIN THE SKIN OF DOGS/

Authors
MASON IS LLOYD DH
Citation
Is. Mason et Dh. Lloyd, EVALUATION OF COMPOUND-48 80 AS A MODEL OF IMMEDIATE HYPERSENSITIVITYIN THE SKIN OF DOGS/, Veterinary dermatology, 7(2), 1996, pp. 81-83
Citations number
15
Categorie Soggetti
Veterinary Sciences
Journal title
Veterinary dermatology → ACNP
ISSN journal
09594493
Volume
7
Issue
2
Year of publication
1996
Pages
81 - 83
Database
ISI
SICI code
0959-4493(1996)7:2<81:EOC8AA>2.0.ZU;2-K
Abstract
The macroscopic and histological effects of intradermal injection of c ompound 48/80 were investigated in dogs. Dose-dependent increases in s kin-fold thickness were induced at injection sites and histopathologic al examination of skin biopsy specimens revealed evidence of mast cell degranulation and cellular infiltration. Intradermal compound 48/80 m ay form a useful model for studies of canine hypersensitivity disorder s including atopic dermatitis.