PREVENTION OF SPONTANEOUS AUTOIMMUNE-THYROIDITIS IN THE OBESE STRAIN (OS) CHICKENS BY TREATMENT WITH A MONOCLONAL ANTI-CD4 ANTIBODY

Authors
CIHAK J HOFFMANNFEZER G WASL M MERKLE H KASPERS B HALA K PLACHY J WICK G
Citation
J. Cihak et al., PREVENTION OF SPONTANEOUS AUTOIMMUNE-THYROIDITIS IN THE OBESE STRAIN (OS) CHICKENS BY TREATMENT WITH A MONOCLONAL ANTI-CD4 ANTIBODY, Journal of veterinary medicine. Series A, 43(4), 1996, pp. 211-216
Citations number
16
Categorie Soggetti
Veterinary Sciences
Journal title
Journal of veterinary medicine. Series A → ACNP
ISSN journal
0931184X
Volume
43
Issue
4
Year of publication
1996
Pages
211 - 216
Database
ISI
SICI code
0931-184X(1996)43:4<211:POSAIT>2.0.ZU;2-6
Abstract
Untreated control OS chickens develop spontaneous autoimmune thyroidit is (SAT). In contrast, OS chickens treated with a monoclonal anti-CD4 antibody failed to develop SAT. The preventive effect of anti-CD4 anti body on SAT was associated with the marked depletion of CD4(+) T-cells by anti-CD4 treatment. These results indicate that CD4(+) T-cells pla y a crucial role in SAT of OS chickens.