An unusual case of hemolytic disease of the newborn caused by anti-M a
ntibody is presented. Hyperbilirubinemia was noted in a full-term baby
boy at 4 days of age. A total of 160 mL of M-positive packed red bloo
d cells from the baby's father were transfused during the next 9 days
and the hemolytic process became aggravated. The baby was referred to
our hospital at 14 days of age. Maternal anti-M was detected and the b
aby was transfused with 50 mL of M-negative packed red blood cells. Th
e baby's condition stabilized and he was discharged uneventfully at 18
days of age.