RECURRENCE OF SARCOIDOSIS FOLLOWING INTERFERON-ALPHA THERAPY FOR CHRONIC HEPATITIS-C

We report a 67-year-old male patient with a known history of sarcoidos is in remission who had recurrent sarcoidosis following a five-month a dministration of interferon alpha (IFN-alpha) for chronic hepatitis C. He developed bilateral swelling of the parotid glands and bilateral d iffuse reticulonodular pulmonary parenchymal opacities on chest roentg enograms. Serum angiotensin converting enzyme (ACE) levels and soluble IL-2 receptor levels were high and a transbronchial lung biopsy revea led noncaseating granulomas. The abnormalities on both laboratory data and chest roentgenograms were resolved after administration of oral p rednisolone.