FAMILIAL TYPE-V HYPERLIPOPROTEINEMIA WITH HYPER-REMNANT-LIKE PARTICLE-CHOLESTEROL ACCOMPANIED WITH APOLIPOPROTEIN E3 E4 PHENOTYPE/

A 41-year-old woman and her 2 sons had Type V hyperlipoproteinemia. In terestingly, the patient and her younger son had higher levels of remn ant-like particle (RLP)-cholesterol than her elder son; the former two had apolipoprotein E phenotype E3/E4, while the latter had E3/E3, Hyp er-RLP-ch levels may be associated with the apolipoprotein E4 phenotyp e, Moreover, after administration of bezafibrate, the patient's trigly ceride, RLP-cholesterol and RLP-triglyceride levels decreased markedly and the chylomicron fraction disappeared, Further studies may be nece ssary to determine if hypertriglyceridemic patients with or without ap olipoprotein E4 show a greater reduction in serum TG levels with lipid -lowering agents.