MCARDLES-DISEASE WITH NON-INSULIN-DEPENDENT DIABETES-MELLITUS - THE BENEFICIAL-EFFECTS OF HYPERGLYCEMIA AND HYPERINSULINEMIA FOR EXERCISE INTOLERANCE

A 64-year-old female with McArdle's disease and non-insulin-dependent diabetes mellitus (NIDDM) is reported, She had none of the characteris tic symptoms of McArdle's disease such as muscle cramps but her serum creatine kinase level was elevated, Muscle biopsy with negative muscle phosphorylase staining showed McArdle's disease, Modified forearm isc hemic exercise test was done at two conditions; fasting and two hours after a meal, When fasting, the level of lactic acid did not elevate a fter exercise, After a meal, however, the serum lactic acid level rose with the elevation of plasma glucose and IRI, Thus, we suggested that high plasma glucose and insulin due to NIDDM may induce blood-borne g lucose uptake with exercise.