SYNTHESIS OF A NEW CHIRAL PEPTIDE ANALOG OF DNA USING ORNITHINE SUBUNITS AND SOLID-PHASE PEPTIDE-SYNTHESIS METHODOLOGIES

In this paper we describe the synthesis of chiral peptide nucleic acid s (PNAs) 1-3 using SPPS methodologies. Starting material for the monom er units was the commercially available amino acid ornithine. L- or D- ornithine and the nucleo-base thymine were linked by a carboxymethylen e spacer giving the chiral monomers L-7 and D-7. The SPPS was performe d according to the Fmoc strategy.