REACTIONS OF N-HYDROXYSUCCINIMIDE ESTERS OF N-ALKOXYCARBONYL-ALPHA-AMINO ACIDS WITH ACTIVE METHYLENE-COMPOUNDS - SYNTHESIS OF 3-SUBSTITUTEDTETRAMIC ACIDS

Authors
DETSI A MARKOPOULOS J IGGLESSIMARKOPOULOU O
Citation
A. Detsi et al., REACTIONS OF N-HYDROXYSUCCINIMIDE ESTERS OF N-ALKOXYCARBONYL-ALPHA-AMINO ACIDS WITH ACTIVE METHYLENE-COMPOUNDS - SYNTHESIS OF 3-SUBSTITUTEDTETRAMIC ACIDS, Chemical communications, (11), 1996, pp. 1323-1324
Citations number
18
Categorie Soggetti
Chemistry
Journal title
Chemical communications → ACNP
ISSN journal
13597345
Issue
11
Year of publication
1996
Pages
1323 - 1324
Database
ISI
SICI code
1359-7345(1996):11<1323:RONEON>2.0.ZU;2-J
Abstract
The N-hydroxysuccinimide esters of N-alkoxycarbonyl-alpha-amino acids react with active methylene compounds (cyanoacetic esters,malonic and acyl acetic esters), under basic conditions, to produce 3-substituted N-alkoxycarbonyl tetramic acids; in the case of the N-hydroxysuccinimi de esters derived from L-aminoacids, the corresponding optically activ e tetramic acids are obtained.