K. Frantz et al., THE LOCOMOTOR EFFECTS OF A PUTATIVE DOPAMINE D-3 RECEPTOR AGONIST IN DEVELOPING RATS, European journal of pharmacology, 302(1-3), 1996, pp. 1-6
Dopamine receptors have been categorized into subfamilies D-1 and D-2,
each with separate roles in dopamine-mediated behaviors. Of the D-2 s
ubfamily, the dopamine D-3 receptor has been cloned, but the behaviora
l effects of selectively stimulating the D-3 receptor an largely unkno
wn. The purpose of this study was to quantify the locomotor responses
of developing rats to the putative dopamine D-3 receptor agonist, 7-hy
droxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT). One of three doses
of 7-OH-DPAT (0.01, 0.10, 1.00 mg/kg) or saline was injected subcutane
ously into rats at the age of 10, 20, 30, or 60 days. Five minutes aft
er the injection, rats were placed in automated activity monitors whic
h recorded locomotor behavior at 5 min intervals for 2 h. The high dos
e of 7-OH-DPAT increased locomotor activity in rats of all ages. The m
edium and low doses increased activity in 10- and 20-day-old rats but
not in 30- or 60-day-old rats. The level of drug-induced activation pe
aked at 20 days of age. In 30- and 60-day-old rats, but not 10- and 20
-day-old rats, a period of locomotor suppression preceded the activati
on in response to the high dose of 7-OH-DPAT. In rats aged 20 days and
older, the middle and low doses decreased locomotion early in the tes
t session, but activation did not ensue. This dose-response pattern ac
ross ontogeny closely resembles that induced by quinpirole, an agonist
at the dopamine D-2 receptor subfamily.