INTRAVENOUS MORPHINE INCREASES GLUCOSE-UTILIZATION IN THE SHELL OF THE RAT NUCLEUS-ACCUMBENS

Authors
ORZI F PASSARELLI F LARICCIA M DIGREZIA R PONTIERI FE
Citation
F. Orzi et al., INTRAVENOUS MORPHINE INCREASES GLUCOSE-UTILIZATION IN THE SHELL OF THE RAT NUCLEUS-ACCUMBENS, European journal of pharmacology, 302(1-3), 1996, pp. 49-51
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
302
Issue
1-3
Year of publication
1996
Pages
49 - 51
Database
ISI
SICI code
0014-2999(1996)302:1-3<49:IMIGIT>2.0.ZU;2-A
Abstract
The [C-14]2-deoxyglucose method was applied to measure the effects of the acute intravenous administration of morphine sulphate (0.2-0.4 mg/ kg) on cerebral glucose utilization in rats. Morphine produced dose-de pendent increases of glucose metabolism in the shell of the nucleus ac cumbens, without affecting functional activity in any other brain area . These results provide further evidence for the preferential effects of intravenously abused substances in the shell of the nucleus accumbe ns.