FAILURE OF BUFLOMEDIL TO IMPROVE WOUND-HEALING IN ISCHEMIC SKIN FLAPS

The effect of buflomedil and isoxsuprine on the healing of ischaemic w ounds was investigated using an ischaemic flap model previously evalua ted on rats. The drugs were given twice daily intraperitoneally for a total of nine days starting on the day before operation. The wounds we re tested biomechanically after 10 and 20 days of healing, respectivel y, and the length of surface necrosis on the flaps was measured after 10 days. The study showed no differences in any of the biomechanical ( functional) parameters of the ischaemic wounds compared with the contr ol groups, either after 10 or 20 days of healing. There were no differ ences in the length of surface necrosis on the flaps. Neither of these drugs has so far convincingly proved to be effective in the treatment of ischaemic wounds or flaps.