THE TARGETING OF THE PLASMA-MEMBRANE CALCIUM-PUMP IN THE CELL

The information on the structural determinants that control the cellul ar distribution of P-type pumps is very scarce. However, recent experi ments on the membrane targeting of the plasma membrane Ca2+ pump (PMCA ) have provided interesting leads on the problem: they will be discuss ed in this succinct review. A general introduction on the biochemical properties of the PMCA pump will preface the discussion of the specifi c findings on the role of three distinct regions of the molecule in th e targeting process.