STEREOSELECTIVE DIOXYGENASE-CATALYZED BENZYLIC HYDROXYLATION AT PROCHIRAL METHYLENE GROUPS IN THE CHEMOENZYMATIC SYNTHESIS OF ENANTIOPURE VICINAL AMINOINDANOLS
Dr. Boyd et al., STEREOSELECTIVE DIOXYGENASE-CATALYZED BENZYLIC HYDROXYLATION AT PROCHIRAL METHYLENE GROUPS IN THE CHEMOENZYMATIC SYNTHESIS OF ENANTIOPURE VICINAL AMINOINDANOLS, Tetrahedron : asymmetry, 7(6), 1996, pp. 1559-1562
Enantiopure benzylic alcohols containing two stereogenic centres in a
cis-relationship result from stereoselective monohydroxylation of achi
ral 2-substituted indans in cultures of Pseudomonas putida UV4 and are
used in the chemoenzymatic synthesis of both cis- and trans-aminoinda
nol enantiomers. (C) 1996 Elsevier Science Ltd