A FORMAL SYNTHESIS OF (-)-PUMILIOTOXIN-C

Authors
DAVIES SG BHALAY G
Citation
Sg. Davies et G. Bhalay, A FORMAL SYNTHESIS OF (-)-PUMILIOTOXIN-C, Tetrahedron : asymmetry, 7(6), 1996, pp. 1595-1596
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
7
Issue
6
Year of publication
1996
Pages
1595 - 1596
Database
ISI
SICI code
0957-4166(1996)7:6<1595:AFSO(>2.0.ZU;2-E
Abstract
An asymmetric synthesis of an advanced intermediate in the synthesis o f natural (-)-pumiliotoxin C has been achieved in six steps and in 61% overall yield employing as the key step a highly diastereoselective l ithium amide 1,4-conjugate addition to a dienoic ester derived from (R )-(+)-pulegone. (C) 1996 Elsevier Science Ltd