The incidence of vulvar intraepithelial neoplasia and vulvar cancer se
ems to be increasing in younger women. Early detection is important be
cause the morbidity associated with treatment is high, and the surviva
l of patients with advanced stages of disease is low, Most lesions can
be detected by simple inspection of the vulva in white light. While v
ulvar cancer is rare, it should be screened as the first step in every
pelvic exam. Target populations for future prevention or chemoprevent
ion trials might be smokers with human papillomavirus lesions, patient
s with vulvar intraepithelial neoplasia, or women at risk for recurren
ces of vulvar cancer.