CARRIER DETECTION IN DUCHENNE AND BECKER MUSCULAR-DYSTROPHY USING DINUCLEOTIDE REPEAT POLYMORPHISMS - A STUDY IN MEXICAN FAMILIES

Authors
ARENAS D CORAL R CISNEROS B PENALOZA L SALAMANCA F KOFMAN S MERCADO R MENDEZ J MARTINEZ C MONTANEZ C
Citation
D. Arenas et al., CARRIER DETECTION IN DUCHENNE AND BECKER MUSCULAR-DYSTROPHY USING DINUCLEOTIDE REPEAT POLYMORPHISMS - A STUDY IN MEXICAN FAMILIES, Archives of medical research, 27(2), 1996, pp. 151-156
Citations number
24
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Archives of medical research → ACNP
ISSN journal
01884409
Volume
27
Issue
2
Year of publication
1996
Pages
151 - 156
Database
ISI
SICI code
0188-4409(1996)27:2<151:CDIDAB>2.0.ZU;2-#
Abstract
Becker muscular dystrophy, dinucleotide sequences repeats (CA) of intr ons 44, 45, 49 and 50 were used as well as two markers located at the 5' and 3' ends of the dystrophin gene, Haplotypes of the unaffected an d affected persons of ten DMD/BMD Mexican families were determined, Fi fty eight females were studied, 30 of whom were at-risk STR haplotypes , Furthermore, it was possible to identify a recombination event in th e dystrophin gene in one family, and a gonadal mosaicism was found in another family.