Je. Macor et al., AN IMPROVED SYNTHESIS OF THE UNIQUE ANTIMIGRAINE AGENT CP-122,288 - ABROMINE ATOM PASSENGER IN AN INTRAMOLECULAR HECK REACTION, Tetrahedron letters, 37(25), 1996, pp. 4289-4292
Utilizing a 2,6-dihromoaniline (6b) in place of the original monobromo
aniline in the indole-forming intramolecular Heck reaction allows for
a greater than two-fold improvement in the overall yield of CP-122,28
8. The second bromine is carried through unmolested, forming a 7-bromo
indole analog of CP-122,288 (1b). This result might represent a novel
approach to 7-substituted indole derivatives. Copyright (C) 1996 Elsev
ier Science Ltd.