AN IMPROVED SYNTHESIS OF THE UNIQUE ANTIMIGRAINE AGENT CP-122,288 - ABROMINE ATOM PASSENGER IN AN INTRAMOLECULAR HECK REACTION

Authors
MACOR JE OGILVIE RJ WYTHES MJ
Citation
Je. Macor et al., AN IMPROVED SYNTHESIS OF THE UNIQUE ANTIMIGRAINE AGENT CP-122,288 - ABROMINE ATOM PASSENGER IN AN INTRAMOLECULAR HECK REACTION, Tetrahedron letters, 37(25), 1996, pp. 4289-4292
Citations number
4
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
25
Year of publication
1996
Pages
4289 - 4292
Database
ISI
SICI code
0040-4039(1996)37:25<4289:AISOTU>2.0.ZU;2-I
Abstract
Utilizing a 2,6-dihromoaniline (6b) in place of the original monobromo aniline in the indole-forming intramolecular Heck reaction allows for a greater than two-fold improvement in the overall yield of CP-122,28 8. The second bromine is carried through unmolested, forming a 7-bromo indole analog of CP-122,288 (1b). This result might represent a novel approach to 7-substituted indole derivatives. Copyright (C) 1996 Elsev ier Science Ltd.