TRIMETHYLAIMINE N-OXIDE - A NOVEL REAGENT FOR THE PROMOTION OF THE RETRO-ALDOL REACTION OF R106-1 (LY295337)

Authors
RODRIGUEZ MJ ZWEIFEL MJ
Citation
Mj. Rodriguez et Mj. Zweifel, TRIMETHYLAIMINE N-OXIDE - A NOVEL REAGENT FOR THE PROMOTION OF THE RETRO-ALDOL REACTION OF R106-1 (LY295337), Tetrahedron letters, 37(25), 1996, pp. 4301-4304
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
25
Year of publication
1996
Pages
4301 - 4304
Database
ISI
SICI code
0040-4039(1996)37:25<4301:TN-ANR>2.0.ZU;2-R
Abstract
The retro-aldol reaction of R106-1 (LY295337), 1 using trimethylamine N-oxide (TNO) facilitates the removal of the tertiary hydroxy group ge nerating R106-sarcosine, 2 a key synthetic intermediate. The reagent i s highly reproducible and provides high yields with no major side prod ucts. A side by side comparison of TNO vs. traditional bases is descri bed. Copyright (C) 1996 Elsevier Science Ltd.